By enabling instant-on and purpose-built applications(TM) for PCs, a new platform from Phoenix will transform the user experience with new levels of security, reliability, ease of use, and low power consumption MILPITAS, Calif., Nov. 5 /Xinhua-PRNewswire/ -- Phoenix Technologies Ltd. (Nasdaq: PTEC), the global leader in core systems firmware, today announced Phoenix HyperSpace(TM), an innovative platform that promises to ignite a PC revolution by transforming the mobile personal computing experience. Enhanced by Intel(R) processor technology, Phoenix HyperSpace(TM) provides a secure foundation of `embedded simplicity.' PC OEMs can now offer highly-efficient, instantly available applications that promise to deliver new levels of security, up-time, system reliability, remote management, and ease-of-use to PC users. ( Logo: http://www.newscom.com/cgi-bin/prnh/20070410/SFTU048LOGO ) The HyperSpace platform provides a unique computing environment that PC designers, security innovators and content providers can use to create instant-on applications that are available before, during, and after Windows boot up and shut down. Operating like self-contained appliances, these purpose-built applications will be embedded into new computers by PC system vendors. Next-generation PC users will benefit from one-click remote system maintenance, repair, lower battery consumption and embedded security providing stronger protection than is currently available, along with a host of possible applications and content such as instant-on multi-media players, IP soft phones, email, instant messaging, Web 2.0 browsing, safe shopping and more. Phoenix has already demonstrated prototype, proof-of-concept applications that show the possibilities of the new HyperSpace platform. HyperSpace delivers an elegant, high-performance, low battery-consumption environment which enables mobile PC users to be productive at all times. "For most of us, today's computing experience is a lot like air travel -- offering tremendous possibilities, but plagued with security issues, delays and system failures," said Woody Hobbs, President & CEO of Phoenix Technologies. "HyperSpace introduces a new framework to transform the personal computing experience through purpose-driven appliances(TM) that work within the HyperSpace environment. Working together with our partners within the PC ecosystem, we believe HyperSpace will ignite a new revolution of innovation built on the foundation of embedded simplicity." The HyperSpace platform is enabled by an efficient hypervisor from Phoenix called HyperCore(TM), which is embedded within the core system firmware, or BIOS. HyperCore is a lightweight Zoned Virtual Machine Monitor (ZVMM) that runs specialized core services side-by-side with Windows. HyperSpace products will offer isolation and high performance delivered by optimizing HyperSpace for capabilities delivered in Intel(R) Core(TM) 2 Duo processors, Intel(R) vPro(TM) and Intel(R) Centrino(TM) Pro processor technology, including enhanced Intel(R) Virtualization Technology and Intel(R) Trusted Execution Technology. "Intel(R) Core(TM) 2 Duo processors and Intel(R) vPro(TM) processor technology enable the development of more secure and better performing virtualization infrastructure," said Gregory Bryant, Vice President and General Manager for Intel's Digital Office Platform Division. "Intel is pleased to see Phoenix embracing Intel's technologies to deliver innovative products for PC clients." Leslie Fiering, Research VP at Gartner, said, "Client computing combines two worlds -- on one side, users want their work and personal lives to be empowered by an instant-on and always available PC with ubiquitous network access and easy-to-use applications. On the business side, beleaguered IT organizations are working with shrinking budgets and face growing concerns over security. The industry will welcome a solution that holds the promise of satisfying both PC user needs as well as IT remote management and security needs." Phoenix Technologies is actively collaborating with industry partners, PC OEMs/ODMs, ISVs and Web 2.0 providers to introduce the next-generation of PCs with embedded simplicity. About Phoenix Technologies Phoenix Technologies Ltd. (Nasdaq: PTEC) is the global market leader in systems firmware that provides the most secure foundation for today's computing environments. The Company established industry leadership with its original BIOS product in 1983, and today has 155 technology patents, has shipped in over one billion systems, and continues to ship in over 125 million new systems each year. The PC industry's top builders and specifiers trust Phoenix to pioneer open standards and deliver innovative solutions to help them accelerate time to market, differentiate products and increase profits. Phoenix is headquartered in Milpitas, California with offices worldwide. For more information, visit http://www.phoenix.com. Phoenix, Phoenix Technologies, and the Phoenix Technologies logo are trademarks and/or registered trademarks of Phoenix Technologies Ltd. All other trademarks are the property of their respective owners. Safe Harbor With the exception of historical information, the statements in this release include forward-looking statements within the meaning of Section 27A of the Securities Act of 1933, as amended, and Section 21E of the Securities Exchange Act of 1934, as amended, regarding, but not limited to, the potential transformative impact of the HyperSpace platform and the HyperCore hypervisor on the PC industry and PC users, the functionality and features of this new platform, the adoption of this new platform by Phoenix's partners and customers, and the potential applications that may be based on this new platform These statements involve risks and uncertainties, including: unexpected technical challenges and delays, including code bugs and glitches; the product offerings of competitors, especially with respect to functionality and time-to-market; price competition; our ability to successfully market and sell the HyperSpace platform to our customers; the ability of our customers to introduce and market products that incorporate and leverage the HyperSpace platform; end-market demand for applications that may be enabled by the HyperSpace platform; and our ability to adequately protect our intellectual property rights. For a further list and description of risks and uncertainties that could cause actual results to differ materially from those contained in the forward looking statements in this release, we refer you to the Company's filings with the Securities and Exchange Commission, including, but not limited to, its annual report on Form 10-K and quarterly reports on Form 10-Q. All forward-looking statements included in this release are based upon assumptions, forecasts and information available to the Company as of the date hereof, and the Company assumes no obligation to update any such forward-looking statements. For more information, please contact: Media & Analyst Relations: Phoenix Technologies, Global Communications Tel: +1-408-570-1946 Email: public_relations@phoenix.com Scott Vansickle Global Fluency Tel: +1-650-433-4222 Email: svansickle@globalfluency.com
Structure Provides Flexibility to Initiate Company's Planned 100 Megawatt Thin Film Solar Module Production Facility Build Out ALISO VIEJO, Calif., Nov. 5 /Xinhua-PRNewswire/ -- XsunX, Inc. (OTC Bulletin Board: XSNX), announced today that it has secured a total of $21,000,000 in financing with Fusion Capital Fund II, LLC, a Chicago-based institutional investor, to support the launch of its phased plans to build a 100 megawatt amorphous silicon thin film photovoltaic (TFPV) solar module manufacturing facility. Over the course of 2007, the Company designed a proprietary 25 megawatt TFPV solar module manufacturing system, and developed a phased plan to build and install four of these systems by 2010. XsunX then worked with industry proven and recognized vendors to ensure access to materials and components necessary to meet build schedules under its phased plan. Next, XsunX solicited proposals from over twenty states to ensure that the Company benefited from establishing its new manufacturing facilities in a region providing strong business incentives and an educated workforce. After a review of all submitted proposals, XsunX made a decision to locate their multi-megawatt manufacturing facilities in the State of Oregon, USA. This decision was based on a combination of operating incentives and credits, added to low cost financing opportunities, submitted by the State of Oregon. XsunX then worked to introduce the design and future availability of its XASI-120 solar module to the solar installation industry at key trade shows. These efforts have resulted in over 90 megawatts of module pre-manufacture reservations. Finally, the Company set out to select a strong investment partner and the right investment structure to finance the first stages of the planned build out of its TFPV manufacturing facilities. Mr. Tom Djokovich, XsunX's CEO, stated, "We owed our investors a well defined plan leveraging a solid mix of key employees, premier vendors, government support, and access to working capital under the best terms, without the burden of unnecessary debt instruments found in many financing agreements. I believe that taking the time to put all of the pieces in place was crucial to providing XsunX the best opportunity for success. One of the last aspects to our plan was to find a solid financing partner that was interested in our business. We looked at quite a few term sheets and, in selecting Fusion Capital, I believe that we found the support we needed on the terms that work best for all of our investors." Upon signing the stock purchase agreement, XsunX received $1,000,000 from Fusion Capital as an initial purchase of common stock under the $21 million commitment, at a price of $.30 per share. After the SEC has declared effective a registration statement related to the transaction, the Company has the right, over a 25-month period, to sell its shares of common stock to Fusion Capital, from time to time, in amounts up to $1 million per sale, depending on certain conditions as set forth in the stock purchase agreement, up to the full aggregate commitment of $21 million. The purchase price of the shares related to the $20 million balance of future funding will be based on the prevailing market prices of the Company's shares at the time of sales without any fixed discount, and the Company will control the timing and amount of any sales of shares to Fusion Capital. There are no negative covenants, restrictions on future fundings, penalties or liquidated damages in the agreement. The common stock purchase agreement may be terminated by XsunX at any time at its discretion without any additional cost to XsunX. The proceeds received by the Company under the common stock purchase agreement are expected to be used to build an initial base production system delivering full size commercial quality solar modules, and initiate the manufacture of the first of four (4) planned 25 megawatt systems under the Company's planned 100 megawatt thin film solar module production facility. Proceeds may also be used to lease and prepare manufacturing facilities with the necessary support systems for the manufacturing line, inventory, staff, and general working capital. A more detailed description of the agreement is set forth in the Company's Current Report on Form 8-K recently filed with the SEC which the Company encourages be reviewed carefully. About XsunX Fusion Capital Fund II, LLC is an institutional investor based in Chicago, Illinois with a fundamental investment approach. Fusion Capital invests in a wide range of companies and industries emphasizing life sciences, energy and technology companies. Its investments range from special situation financing to long-term strategic capital. About Fusion Capital Fusion Capital Fund II, LLC is an institutional investor based in Chicago, Illinois with a fundamental investment approach. Fusion Capital invests in a wide range of companies and industries emphasizing life sciences, energy and technology companies. Its investments range from special situation financing to long-term strategic capital. Safe Harbor Statement: Matters discussed in this press release contain forward-looking statements within the meaning of the Private Securities Litigation Reform Act of 1995. When used in this press release, the words "anticipate," "believe," "estimate," "may," "intend," "expect" and similar expressions identify such forward-looking statements. Actual results, performance or achievements could differ materially from those contemplated, expressed or implied by the forward-looking statements contained herein. These forward-looking statements are based largely on the expectations of the Company and are subject to a number of risks and uncertainties. These include, but are not limited to, risks and uncertainties associated with: the impact of economic, competitive and other factors affecting the Company and its operations, markets, product, and distributor performance, the impact on the national and local economies resulting from terrorist actions, and U.S. actions subsequently; and other factors detailed in reports filed by the Company. For more information, please contact: Investor Relations XsunX, Inc. Tel: +1-888-797-4527 Web: http://www.XsunX.com
BASINGSTOKE, England, Nov. 5 /Xinhua-PRNewswire/ -- New data presented today at the 40th annual American Society of Nephrology (ASN) meeting and scientific exposition in San Francisco, CA, USA, show that epoetin delta -- the only erythropoiesis-stimulating agent (ESA) produced in a human cell line -- has less pronounced angiogenic properties than darbepoetin alfa in vitro at similar pharmacokinetic concentrations.(1) Angiogenesis, the formation of new blood vessels from pre-existing vessels, plays an important role in tumour growth, malignancy and diabetic retinopathy. The study evaluated the angiogenic potential of human cell-derived epoetin delta and darbepoetin alfa at broad concentration ranges using a novel in vitro model that incorporates key aspects of the complex angiogenesis process.(1) "Although this research is at a very early stage, this data is the first step towards evaluating whether different EPO analogues produce different angiogenic effects," said primary investigator Professor Alan Stitt, Centre for Vision Science, Queen's University, Belfast, Northern Ireland, UK. "In the clinical setting, there are situations where reduced angiogenic potential is beneficial, for example, in patients with malignancies or proliferative retinopathy. Additional studies, in both the non-clinical and clinical setting, are needed to further examine the angiogenic potential and related molecular mechanisms of epoetin delta." The authors of the study concluded that the observed pharmacological effects of epoetin delta and darbepoetin alfa on the angiogenic response may be associated with their different glycosylation patterns at clinically relevant doses.(1) Glycosylation (the process of adding carbohydrate structures to a protein) is dependent on various factors including species and cell type.(2) As epoetin delta is produced in human cells by activating the erythropoietin gene -- and all other commercially available ESAs are presently made in Chinese Hamster Ovary (CHO) cells -- epoetin delta has a different glycosylation pattern to other currently marketed ESAs.(3) Neuropathy also commonly develops in people with diabetes who also suffer from CKD. Additional non-clinical data accepted for publication at ASN show that in rats, epoetin delta corrects the reduced nerve conduction velocity (a parameter of nerve function) associated with neuropathy. This occurred even at doses below those promoting haematopoiesis.(4) "This data is particularly interesting," said primary investigator Professor Norman E Cameron, School of Medical Sciences, University of Aberdeen, Scotland. "We know that ESAs are effective in correcting anaemia, but this data suggests that, at least in the non-clinical setting, epoetin delta may have pleiotropic, non-hematopoietic effects. Further research is needed to investigate whether structural differences across ESA analogues influence diabetic co-morbidities, such as diabetic neuropathy, differently." To further understand the implications of epoetin delta being manufactured in a human cell line, Shire is sponsoring a non-clinical research programme to investigate how epoetin delta affects tissues and processes outside of the haematopoietic system. Of particular interest is whether epoetin delta's human cell derivation may influence co-morbidities of the renal anaemia patient, such as diabetic complications and vascular disease, in a way that is different to ESA's derived from animal cells. The research presented today marks the publication of the first data from the programme. About DYNEPO DYNEPO is the first commercially available ESA produced in a human cell line.(5) This is accomplished by activating the endogenous human erythropoietin gene in a human cell line using specialised gene-activating DNA sequences.(6) All other commercially available ESAs are produced in CHO cells. Anaemic patients with CKD require treatment with an ESA such as DYNEPO in order to increase red blood cell production. DYNEPO is indicated for the treatment of anaemia in patients with chronic renal failure (CRF) and may be used in patients on dialysis and in patients not on dialysis.(7) DYNEPO is a registered trademark of Hoescht GmbH. (i) While common terminology is now chronic kidney disease (CKD), some regulatory agencies have not adopted this terminology, instead they refer to chronic renal failure (CRF); these terms are essentially interchangeable. Notes to editors Shire plc Shire's strategic goal is to become the leading specialty biopharmaceutical company that focuses on meeting the needs of the specialist physician. Shire focuses its business on attention deficit and hyperactivity disorder (ADHD), human genetic therapies (HGT), gastrointestinal (GI) and renal diseases. The structure is sufficiently flexible to allow Shire to target new therapeutic areas to the extent opportunities arise through acquisitions. Shire's in-licensing, merger and acquisition efforts are focused on products in niche markets with strong intellectual property protection either in the US or Europe. Shire believes that a carefully selected portfolio of products with strategically aligned and relatively small-scale sales forces will deliver strong results. The "Safe Harbor" Statement Under the Private Securities Litigation Reform Act of 1995 Statements included herein that are not historical facts are forward-looking statements. Such forward-looking statements involve a number of risks and uncertainties and are subject to change at any time. In the event such risks or uncertainties materialize, Shire's results could be materially affected. The risks and uncertainties include, but are not limited to, risks associated with: the inherent uncertainty of pharmaceutical research; product development including, but not limited to, the successful development of JUVISTA(R) (Human TGF beta 3) and GA GCB (velaglucerase alfa); manufacturing and commercialization including, but not limited to, the launch and establishment in the market of VYVANSE(TM) (Attention Deficit and Hyperactivity Disorder ("ADHD"); the impact of competitive products including, but not limited to, the impact of those on Shire's ADHD franchise; patents including, but not limited to, legal challenges relating to Shire's ADHD franchise; government regulation and approval including, but not limited to, the expected product approval date of INTUNIV(TM) (guanfacine extended release) (ADHD); Shire's ability to secure new products for commercialization and/or development; and other risks and uncertainties detailed from time to time in Shire plc's filings with the Securities and Exchange Commission, particularly Shire plc's Annual Report on Form 10-K for the year ended December 31, 2006. References (1) McVicar C, Gardiner T, Stitt A. Human-cell-derived epoetin delta is less angiogenic than darbepoetin alfa in vitro. Poster presented at American Society of Nephrology Renal Week, San Francisco, CA, USA. 2-5 November 2007. (2) Skibeli V, Nissen-Lie G, Torjesen P. Sugar profiling proves that human erythropoietin differs from recombinant human erythropoietin. Blood 2001; 98(13): 3626-3634. (3) Shahrokh Z, Flatman S, Davies M, et al. Erythropoietin produced by a human cell line has only trace levels of potentially immunogenic N-glycolylneuraminic acid residues. Presented at the European Haematology Association 11th Annual Congress, Amsterdam, The Netherlands. 15-18 June 2006. (4) Cameron N and Cotter M. Potential benefits of epoetin delta in diabetic rats: focus on neuropathy. Abstract accepted at American Society of Nephrology Renal Week, San Francisco, CA, USA. 2-5 November 2007. (5) Pratt, R. Epoetin delta for the treatment of anemia in patients with CKD not requiring hemodialysis. Poster presented at American Society of Nephrology Renal Week, San Diego, CA, USA; 14-19 November 2006 (6) Deicher R and Horl W. Differentiating factors between erythropoiesis-stimulating agents. Drugs 2004; 64(5): 499-509. (7) DYNEPO Summary of Product Characteristics. Shire Pharmaceuticals. April 2007. For further information on Shire, please visit the Company's website: http://www.shire.com. For more information, please contact: Investor Relations: Clea Rosenfeld Phone: +44-1256-894-160 Media Shire: Jessica Mann Phone: +44-1256-894-280 Media PR agents for DYNEPO: Resolute Communications May Baccari Phone: +44-207-357-8187 Kirsty Mearns Phone: +44-207-357-8187
- Good Perspectives for Sino-Berlin Business Relations BERLIN, Nov. 5 /Xinhua-PRNewswire/ -- Berlin Mayor and Senator for Economics, Technology, and Women's Affairs Harald Wolf will be visiting Hong Kong, Shenzhen, and Beijing November 7-12, where he'll be meeting and holding talks with politicians and business representatives. Senator Wolf says of his trip, "I intend to entrench existing contacts, and inform Chinese companies about the opportunities for investment in Berlin. A new airport is currently being built in Berlin that is an hour's flight closer to Asia than any other European airport that can be reached directly by air." Berlin is one of only two German cities in the list of the top 50 foreign investment locations for Chinese companies compiled by the Chinese Economics Ministry and the China International Institute of Multinational Corporations. At present there are about 200 Chinese-run firms in Berlin, and another 20 or so are planning to settle there. Some 6,000 Chinese live in the German capital city. Berlin-based companies increased their trade with China by a factor of six from 1996 to 2006. Over the same period, imports from China rose more than fivefold. In Hong Kong Senator Wolf is due to hold talks with municipal leaders and visit the science park. In Shenzhen he will be visiting HYT, a radio device manufacturer. He will also be attending the Shenzhen-Berlin Economic Cooperation Forum, where he will present the investment opportunities in Berlin to representatives from several hundred Chinese companies. In Beijing the senator will be visiting the Berlin Olympic Pavilion and find out more about the Sino-German co-production 'Laura's Star II' involving Berlin-based animation company Cartoon Film. In all three cities he will be talking to airlines interested in operating direct flights to Berlin. The construction of the new Berlin-Brandenburg International Airport (BBI) will create the most modern airport in Europe. The BBI is due to begin operating in 2011, and is expected to process an initial 25 million passengers a year, though it will have the capacity to handle up to 40 million. Given its proximity to Asia vis-a-vis other European airports, the BBI will be ideal for new direct connections between the two continents. The Berlin delegation's trip was organized by Berlin Partner GmbH, the company commissioned by the Berlin government to attract investors, advise local companies on foreign trade, and market the German capital city. Further information about Berlin Partner (in German and Chinese): http://www.berlin-china.net Further information about the investor conference (in English and Chinese): http://www.shenzhen-berlin.com For more information, please contact: Berlin Partner GmbH Ludwig Erhard Haus Fasanenstrasse 85 D-10623 Berlin Website: http://www.berlin-partner.de Christoph Lang Head, Press and Public Relations Tel: +49-30-39980-123 Fax: +49-30-39980-113 Mobile: +49-1577-3998-123 Email: Christoph.Lang@berlin-partner.de
HONG KONG, Nov. 5 /Xinhua-PRNewswire/ -- Arrow Asia Pac Ltd., a business unit of Arrow Electronics, Inc. (NYSE: ARW), announced that it was ranked among the top-five companies in the InformationWeek China 100, an annual listing of the most innovative users of information technology in China. (Logo: http://www.xprn.com/xprn/sa/200703021139.JPG ) "We are honored to be recognized again as one of China's most innovative users of information technology in the InformationWeek China 100 listing," said Peter Kong, president of Arrow Asia Pac. "This recognition clearly reflects our industry leadership position. In our journey to be the clear number one in Asia, we will continue to create a competitive advantage and deliver value for our customers and suppliers through utilizing technology to accelerate improvements in business processes." The InformationWeek China 100 considered over 6,000 companies from 35 industries in mainland China. It included a quantitative and qualitative analysis of technology initiatives and priorities, and responses were evaluated and weighted and combined into a total score that formed the basis for the ranking. About Arrow Asia Pac A business unit of Arrow Electronics, Inc. (NYSE: ARW), Arrow Asia Pac is one of Asia-Pacific's leading electronic component distributors. In addition to its regional headquarters in Hong Kong, Arrow Asia Pac operates 51 sales offices, four primary distribution centers and 12 local warehousing facilities in 11 countries/territories across Asia. Providing a full range of semiconductors, passive, electromechanical and connector products from over 170 leading international suppliers, Arrow Asia Pac serves more than 10,000 original equipment and contract manufacturers and commercial customers in Asia-Pacific. Visit us at http://www.arrowasia.com . For more information, please contact: Ray Leung Marketing Communications Director Arrow Asia Pac Ltd. Tel: +852-2484-2484 Email: marcom.asia@arrowasia.com Grace Kung Marketing Communications Manager Tel: +852-2484-2682 Email: grace.kung@arrowasia.com
LONDON, Nov. 5 /Xinhua-PRNewswire/ -- At FI Europe, the world's largest food ingredients event, with a record breaking 23000 visitors and over 1,000 exhibitors in London this week, a distinguished panel of judges has awarded its prestigious Gold Award to EBI Food Safety of The Netherlands. In its fight against Listeria, and other dangerous bacteria, the food industry has embraced a 'green' solution, using bacteriophages as the way to go. EBI Food Safety, first-to-market with a commercial bacteriophage product, fended off competition from eight other finalists to scoop the Oscar of the Food Industry, for its LISTEX(TM) product against Listeria monocytogenes, the deadly food pathogens. At a glittering ceremony in London's Excel Centre, the awards came at the end of a day of non-stop deliberation by the judges. "This year's FI Awards have been the most exciting ever" said Henry Dixon, chairman of the judging committee and director of international food marketing communications agency Barret Dixon Bell. "We received over 50 entries, and had a really good spread of innovations and market factors. They were extremely strong finalists". "LISTEX(TM) is a true innovation, a new approach to an urgent and growing problem that affects both consumers and manufacturers" said Dixon, explaining the judges' reason for choosing EBI Food Safety as the winner of the Gold Award. The FI Awards, which have been running since 1994, are one of the most eagerly anticipated events in the food industry calendar, and this year was no exception. "I think the FI Awards are particularly special in that they really make a difference - as evidenced by the amount of interest that has been shown in them - journalists from around the globe have been desperate to find out who has won", said Dixon. LISTEX(TM) effectively eliminates Listeria monocytogenes, without affecting the other properties of the food. It is a safe and natural product, which is easy to apply in a variety of Listeria-susceptible products, such as hams and hot dogs, cheese, fish and many RTE-products. It addresses a multi-billion dollar industry problem, on account of Listeria's high mortality (20-30%) and ability to grow at refrigerated temperatures and in low oxygen environments such as packaged foods. First associated with a food borne outbreak in 1981, killing 7, Listeria monocytogenes is now responsible for almost half of all deaths caused by food pathogens. Other potentially fatal pathogens are Salmonella, Campylobacter and E-coli, for which EBI Food Safety is also developing bacteriophage products. EBI Food Safety's CEO, Mark Offerhaus: "We are honoured by the judges' decision. This choice is a confirmation from the industry that the use of phages is a logical one. Last month the largest frozen hamburger producer in the US went out of business, just two weeks after it's first ever product recall. The consequences of a contaminated product reaching the market can be catastrophic. Use of natural phages translates into risk-reduction, valued by shareholders and consumers alike." About EBI Food Safety EBI Food Safety (http://www.ebifoodsafety.com), located in Wageningen ("Food Valley"), The Netherlands, develops and markets natural bacteriophage products against dangerous food pathogens and is viewed as product leader in this field. Earlier this year EBI Food Safety was elected as one of Holland's 25 most promising young enterprises by FEM Business Magazine. The company's scientific network includes collaborations with universities and research centers around the world. For more information, please contact: Mark Offerhaus, CEO EBI Food Safety Phone: +31-0-654-913-176 Email: m.offerhaus@ebifoodsafety.com or info@ebifoodsafety.com
Investigational compound reduces risk of major cardiovascular events by 19 percent, significantly improves net clinical benefit despite increased bleeding TOKYO and INDIANAPOLIS, Nov. 5 /Xinhua-PRNewswire/ -- In the pivotal Phase III head-to-head TRITON TIMI-38 clinical trial, the investigational antiplatelet agent prasugrel produced a highly significant 19 percent reduction in relative risk (p=0.0004) for the composite endpoint of cardiovascular death, non-fatal heart attack or non-fatal stroke when compared with clopidogrel (Plavix(R)/Iscover(R)) in the treatment of patients across the full spectrum of acute coronary syndrome undergoing percutaneous coronary intervention. ( Logo: http://www.newscom.com/cgi-bin/prnh/20070601/CLF003LOGO ) A significant reduction in the risk for the composite endpoint favoring prasugrel (60 mg loading dose/10 mg maintenance dose) over clopidogrel (300 mg LD/75 mg MD) was observed as early as three days. The absolute difference in this endpoint continued to increase over the course of the 15-month, 13,608-patient trial. In the important subgroup of patients with diabetes, prasugrel reduced the relative risk of cardiovascular death, non-fatal myocardial infarction and non-fatal stroke by 30 percent (p<0.001). In addition, in the key secondary endpoint of stent thrombosis, prasugrel reduced the recurrence of stent thrombosis (a new clot that develops at the stent site) by 52 percent (p<0.0001). TRITON also showed that treatment with prasugrel significantly reduced the relative risk of cardiovascular death, non-fatal heart attack and non-fatal stroke by 21 percent in patients with STEMI (ST-elevation myocardial infarction, or high-risk heart attack) (p=0.02) and 18 percent in patients suffering from UA (unstable angina, or chest pain)/NSTEMI (non-STEMI) (p=0.002). In addition, prasugrel-treated patients experienced a 34 percent decline in urgent target vessel revascularization (a procedure to reopen blocked arteries) (p<0.001) and a 42 percent reduction in heart attack with subsequent death from cardiovascular causes (p=0.02). While the overall incidence of non-CABG (coronary artery bypass grafting) bleeding in TRITON was low in both the prasugrel and clopidogrel treatment groups, prasugrel-treated patients experienced a statistically significant increase in non-CABG (coronary artery bypass grafting) major bleeding compared to clopidogrel-treated patients (2.4 vs. 1.8 percent, or 146 vs. 111 patients, p=0.03), including higher rates of life-threatening bleeding (1.4 vs. 0.9 percent, or 85 vs. 56 patients, p=0.01). Though infrequent, fatal bleeding was statistically more frequent among prasugrel-treated than clopidogrel-treated patients (0.4 percent vs. 0.1 percent, or 21 vs. five patients, p=0.002). However, death from cardiovascular causes occurred less frequently among prasugrel-treated patients than clopidogrel-treated patients (2.1 percent vs. 2.4 percent, or 133 vs. 150 patients, p=0.31), as did all-cause death (3.0 percent vs. 3.2 percent, or 188 vs. 197 patients, p=0.64). The study identified three distinct patient subpopulations with a higher risk of major bleeding in both treatment arms - patients who were 75 years of age or older, weighed less than 60 kg (132 lbs.), or had a prior history of transient ischemic attack (TIA) or stroke. Researchers are evaluating pharmacokinetic data from several prasugrel studies, including TRITON, to determine whether a lower dose of prasugrel might be appropriate for some patients. Among patients without any of these risk factors (80 percent of the 13,608-patient TRITON study), there was no significant difference in major bleeding between prasugrel- and clopidogrel-treated patients (2 percent vs. 1.5 percent, p=0.17). Based on an analysis using the combined endpoint of all-cause death, heart attack, stroke and major bleeding, the net clinical benefit for prasugrel compared with clopidogrel was a significant 13 percent reduction in overall events (12.2 vs. 13.9, p=0.004). In the subpopulations defined as being at greater risk of bleeding, the net clinical benefit was not different between prasugrel- and clopidogrel-treated patients (p=0.43). Without the subpopulations defined as being at greater bleeding risk, the net clinical benefit was 20 percent (10.2 vs. 12.5, p<0.001). Overall, for every 1,000 people treated with prasugrel compared to clopidogrel in the study, there were 23 fewer heart attacks and an additional six major bleeding complications. "Our study provides compelling evidence that the prasugrel regimen tested is superior to standard dose clopidogrel as an antiplatelet therapy to support patients undergoing coronary stenting," said Elliott Antman, M.D., senior investigator with the TIMI Study Group at Harvard Medical School and director of the Samuel A. Levine Cardiac Unit at Brigham and Women's Hospital in Boston. "With the data from TRITON and other studies, we expect to define populations at particular bleeding risk to help establish clear guidance for using this promising therapy." Antman announced the initial study results today at the American Heart Association's 2007 Scientific Sessions in Orlando, Florida (abstract 07-LBCT-20660-AHA). Prasugrel is being co-developed by Daiichi Sankyo Company, Limited (TSE: 4568) and Eli Lilly and Company (NYSE: LLY). "The TRITON data demonstrate the statistical superiority of this new antiplatelet therapy to prevent heart attacks, and validate our decision to test prasugrel head to head against clopidogrel," said J. Anthony Ware, M.D., Lilly cardiovascular platform leader for prasugrel. "We are very pleased with the trial's outcome and are excited by the potential for these results to help us further tailor prasugrel therapy to assure the greatest benefit from this novel treatment." Cardiovascular disease is the leading cause of death in the U.S. and worldwide, killing 16.7 million people each year(i). Acute heart attacks and unstable angina, called acute coronary syndrome, affect more than 840,000 Americans each year and 800,000 in Europe(i,ii). Utilizing current medical interventions and treatments, 300,000 people continue to experience recurrent heart attacks and 450,000 people die from heart attacks annually in the U.S(iv). "TRITON confirms the statistically superior clinical benefit of prasugrel as a third-generation oral antiplatelet that may advance cardiovascular care," said John Alexander, M.D., M.P.H., global head of research and development, Daiichi Sankyo Company, Limited. "Given the promising TRITON results, Daiichi Sankyo and Lilly are expeditiously finalizing our submission package and are still hopeful to submit to the FDA by year end." About the TRITON TIMI-38 study TRITON TIMI-38 was a Phase III, multi-center, randomized, double blind, parallel group, head-to-head clinical trial comparing the effects of prasugrel versus clopidogrel in patients with acute coronary syndrome undergoing percutaneous coronary intervention (PCI). PCI is a procedure to open blockages in heart arteries including the use of coronary stenting. The study enrolled 13,608 patients at 707 trial sites in 30 countries. The primary endpoint of the study was to compare the effects of prasugrel to clopidogrel on the composite incidence of cardiovascular death, non-fatal heart attack and non-fatal stroke during a median period of at least 12 months following PCI. Key secondary objectives included rehospitalization for a cardiac ischemic event; the need for additional procedures to restore blood flow (urgent target vessel revascularization) at 30 days; and stent thrombosis. Key safety endpoints included non-CABG major, life threatening and minor bleeding as well as the overall safety and tolerability of prasugrel. Patients were randomly assigned to one of two treatment groups and given a loading dose of either prasugrel 60 mg or the approved loading dose of clopidogrel 300 mg anytime between randomization and one hour after the completion of the PCI procedure, followed by a daily maintenance dose of either prasugrel 10 mg or clopidogrel 75 mg. All patients also received a daily low dose of aspirin. Antiplatelet agents are critical for both acute and maintenance therapy to inhibit platelet activation and subsequent aggregation that occur in diseased arteries and as adjunct therapy to invasive procedures such as percutaneous coronary intervention. About prasugrel Daiichi Sankyo Company, Limited (TSE: 4568), and Eli Lilly and Company (NYSE: LLY) are co-developing prasugrel, an investigational oral antiplatelet agent invented by Daiichi Sankyo and its Japanese research partner Ube Industries, Ltd., as a potential treatment, initially for patients with acute coronary syndrome undergoing PCI. Prasugrel works by inhibiting platelet activation and subsequent aggregation by blocking the P2Y12 adenosine diphosphate (ADP) receptor on the platelet surface. Antiplatelet agents prevent platelets from clumping or sticking together, which can result in clogged arteries and may lead to heart attack or stroke. About Daiichi Sankyo Company, Limited Daiichi Sankyo Company, Limited, established in 2005 after the merger of two leading century-old Japanese pharmaceutical companies, is a global pharmaceutical innovator, continuously generating innovative drugs that enrich the quality of life for patients around the world. The company uses its cumulative knowledge and expertise in the fields of cardiovascular disease, cancer, metabolic disorders, and infection as a foundation for developing an abundant product lineup and R&D pipeline. About Eli Lilly and Company Lilly, a leading innovation-driven corporation, is developing a growing portfolio of first in class and best-in-class pharmaceutical products by applying the latest research from its own worldwide laboratories and from collaborations with eminent scientific organizations. Headquartered in Indianapolis, Ind., Lilly provides answers - through medicines and information - for some of the world's most urgent medical needs. This press release contains certain forward-looking statements about the potential of the investigational compound prasugrel (CS-747, LY640315) and reflects Daiichi Sankyo's and Lilly's current beliefs. However, as with any pharmaceutical compound under development, there are substantial risks and uncertainties in the process of development and regulatory review. There is no guarantee that the compound will receive regulatory approval, that the regulatory approval will be for the indication(s) anticipated by the companies, or that later studies and patient experience will be consistent with study findings to date. There is also no guarantee that the compound will prove to be commercially successful. For further discussion of these and other risks and uncertainties, see Lilly's filing with the United States Securities and Exchange Commission and Daiichi Sankyo's filings with the Tokyo Stock Exchange. Daiichi Sankyo and Lilly undertake no duty to update forward-looking statements. Plavix(R)/Iscover(R) are registered trademarks of Sanofi-Synthelabo Inc. P-LLY (i) World Health Organization. The Atlas of Heart Disease and Stroke - Types of Cardiovascular Disease 2005. (ii) American Heart Association. Heart Disease and Stroke Statistics - 2006 Update. Dallas, TX. American Heart Association. (iii) Bertrand CURE study (iv) American Heart Association. Heart Attack and Angina Statistics. URL: http://www.americanheart.org/presenter.jhtml?identifier=4591. Last accessed July 26, 2007. For more information, please contact: Joedy Isert Eli Lilly and Company Cell: +1-317-276-5592 / +1-317-997-8544 Jo-ann Straat Daiichi Sankyo (USA) Tel: +1-973-359-2602 Shigemichi Kondo Daiichi Sankyo (Tokyo) Tel: +81-3-6225-1126
2007年12月03日 プレスリリース ━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━━ 留学支援大手の株式会社ゲートウェイ21(所在地:東京都新宿区 代表取締役社長:福井伴昌)は、2007年12月3日より携帯電話向け海外留学情報提供サービス、『留学するならゲートウェイ21』を開始する。 『留学するならゲートウェイ21』では、ゲートウェイ21の業界最大級のネットワークを活かし、同社が世界13ヶ国31都市に展開する留学プログラムを国別、ジャンル別に紹介。特に、携帯のメインユーザーである10代20代に人気の高い、短期語学留学やホームステイ、ワーキングホリデー、大学留学などのコースを中心に紹介している。
◆対応キャリア: 【株式会社ゲートウェイ21】
株式会社ゲートウェイ21 |
2007年12月03日 報道関係者各位 2007年12月03日 ◆1位は「花王:メリーズ」2位は「P&G:パンパース」~「かぶれない」 たくさんある赤ちゃんの紙おむつ、何を基準に選べばいい?そこでアンケ ■1位「花王:メリーズ」24.9% ■2位「P&G:パンパース」21.2% ■3位「ユニチャーム:ムーニー」 その他、コストパフォーマンス重視で「ユニチャーム:マミーポコ」が13. 詳しいアンケートデータは、はアンケートデータバンクで販売しています。
アンケートデータバンクでは、今後も生活全般に関するアンケート調査を実 《ご担当記者様へ》出産、子育てに関する記事のデータおよび情報としてご |
2007年12月03日 カラフルなオーガニックコットンのベビー服を販売しているyugaは、12月7日にオーガニックコットン歯切れを利用したの手作りワークショップを開催します。場所は板橋のコミュニティカフェ「はぴくす」(http://www.happycs.jp/)にて10時から。 第一弾の今回はスタイ(よだれかけ)を皆さんと作ろうと思います。 赤ちゃんがいる方、これから産まれる方、どなたでも大歓迎です。皆様のご参加を心よりお待ちしています。 参加費:1500円 (ランチセット、利用料込み) お子様づれもOKです。ただしお子様入場料が250円かかります。 会場の都合上、先着10名様とさせていただきますので、「はぴくす」へ電話かEメールにてお早めにお申し込みください。 電話 03-6411-0011 Eメール: info@happycs.jp 主催 株式会社 優雅 www.yugacolor.com 取材、見学ご希望の方は安東裕美までご連絡下さい。 |
2007年12月03日 報道関係者各位 ======================================================================== パワーテクノロジー株式会社(所在地:東京都千代田区 代表:中島正三)は、 『スグソコ』は、主に繁華街にて、「今すぐトイレに行きたい」「今すぐ 検索対象となる設備・お店と地域は以下の通りです。 ■ 対象の設備・お店 ■ 対象のエリア 総計で4,000スポットを検索対象とし、スポットごとに、現地までのルート、 今後も本サービスを中心に、消費者のリアルなニーズに応えていけるよう ※「業界初」は当社調べ(2007年11月時点)
■お問い合わせ |
2007年12月03日 中国語通訳・翻訳の株式会社E&Sインターナショナル(平成17年9月設立 東京都品川区西大井1-1-2-206/代表取締役社長山本栄吉)は英語教師、自習者向けにグリーンウッド・カナダ社製英会話教材のeラーニングサービスを12月1日より開始します。 《英語教師、自習者向けのeラーニング英会話教材のサービスを開始》 【主な特長】
《販売政策と目標》
(注2) ALTE = Association of Language Testers/ヨーロッパ語学検定協会 |
2007年12月03日 ティーエムシー株式会社はレアメタルのリサイクル・回収から精製、生産と3事業を完全に自社内でおこなっています。 あらゆる分野から発生する特殊金属スクラップを独自のノウハウで再資源化へと推し進めていくことがTMCの企業力です。
これからも特殊金属のリサイクルという命題を通じ、社会に貢献できる企業体として絶えまぬ改革と研究開発を通じて、”地球延命”の経営理念を実践してまいります。 この度、日本語版ホームページをリニューアルいたしました。 |
2007年12月03日 ティーエムシー株式会社はレアメタルのリサイクル・回収から精製、生産と3事業を完全に自社内でおこなっています。 あらゆる分野から発生する特殊金属スクラップを独自のノウハウで再資源化へと推し進めていくことがTMCの企業力です。
これからも特殊金属のリサイクルという命題を通じ、社会に貢献できる企業体として絶えまぬ改革と研究開発を通じて、”地球延命”の経営理念を実践してまいります。 この度、日本語版ホームページをリニューアルいたしました。 |
2007年12月03日 ACQULIA(アクリア)2.0のリリースについて 株式会社サンストリーム(代表取締役社長:辻口 智 http://www.sanstream.co.jp 以下、サンストリーム)は、12月3日、H.264(※1)コーデックベースの高画質動画ストリーミングソリューション「ACQULIA(アクリア)」の、初のメジャーバージョンアップとなる「ACQULIA 2.0」をリリースいたしました。
【製品および価格体系の改定】 併せて、モジュール毎の価格と同時接続1ユーザあたりの単価を設定し、通常のライセンスだけでなく、使用期間や用途を限定した安価なライセンスを設定するなど、価格体系の全面改定も行いました。例えばエントリー用としてACQULIA VODシステムを1年間の期限付きライセンスで構成すれば、100万円以下の初期投資にて導入が可能となります。 【用語説明】 【ACQULIAの基本機能】 今後、サンストリームは、多様な動画ストリーミングの活用シーンを想定し、基本となるストリーミングサーバ他、ACQULIAの各モジュールのさらなる機能向上を継続して行っていくとともに、着実なマーケティングをもとに、エンドユーザまたは配信事業者の利便性をさらに高めるため、必要な機能の開発を積極的に行ってまいります。 【パッケージ価格例】 【お問合せ先】 【関連リンク】 |
2007年12月03日 ■ホワイトホンは、インターホンと携帯電話を融合させた、受話器を取るだ けで会話のできる直通電話です。 ■携帯電話を接続して使用しますが、受話器を取るだけで指定先の電話と会 話のできる、世界初の画期的な製品です。 ■国内で同様製品のの販売は当社のみ、アイデア次第で用途は無限です、他 社との競合は一切無い製品です。 ■製品はHPで、インターフォン・モバイル2と紹介されています、詳細は HPをご覧下さい。 ■用途事例 ■「ホワイトホン」販売代理店のお問合せは |
2007年12月03日 インターネットを活用したマーケティングソリューションを提案する株式会社エイジア(本社:東京都品川区、社長:江藤 晃、以下当社)は、自社開発したe-CRMシステム「WEB CAS」シリーズ(http://webcas.azia.jp/)のメール共有管理システム「WEB CAS mailcenter」(http://webcas.azia.jp/mailcenter/index.html)を、携帯電話向けコンテンツ配信事業等を行う株式会社アイフリーク(本社:福岡県福岡市、社長:永田 万里子、以下アイフリーク)に提供いたしました。 アイフリークは、携帯電話向けHTMLメール(※)素材のコンテンツ配信を中心に、エンターテインメント性を重視したモバイルコンテンツプロバイダとして、コミュニケーションビジネスの創造に取り組んでいます。主に「デコメ★コレクション」などの携帯電話向けHTMLメール素材配信ポータルサイトをはじめ、電子コミック、待受画像、ゲームなどのデジタルコンテンツを提供するモバイルサイトを企画・制作・運営しております。 このたび同社では、各サイトの会員からの問い合わせに、より迅速かつ適切に対応して顧客満足度を向上させるため、社内のサポート体制の再構築を実施し、合わせて問い合わせメールを一元管理するシステムを採用することといたしました。 <メール共有管理システム「WEB CAS mailcenter」について>
(※) 携帯電話向けHTMLメール とは ■株式会社アイフリークの概要 ■株式会社エイジアの概要
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2007年12月03日 □■□■□■□■□■□■□■□■□■□■□■□■□■□■□■□■□■□ ■掲載企業大幅増加、掲載企業検索システムバージョンアップにより、 ■マーケティング支援.jpを基点として生まれた企業提携による新商品 ■デジタルブック技術「リアルリード」により、アイ・エム・プレス出版物 マーケティング支援.jpプロジェクト(主催:株式会社アイ・エム・プレス サイト表現も、Flashによる動画表現、デジタルブック表現を装備する 近年、関心の高まっているCRM、コールセンター、ダイレクトマーケティ 「マーケティング支援.jp」では、立ち上げ当初からの“売るための機能” 変化の激しいマーケティング環境にあって、ビジネスを成功に導くため 詳細は以下のとおりです。 1.今回、新たに掲載する主な企業 (1)スプリームシステムコンサルティング株式会社 (2)RealRead Inc CRM対応デジタルブック技術「リアルリード」 (3)通販惑星株式会社、株式会社WEMA、クレス株式会社、 2.検索システムのバージョンアップ 9月25日のプレオープン以来、お客様の声を収集し、様々なニーズ 3.マーケティング支援.jpコラボレーション商品第一弾「デカEC」 「デカEC」は、マーケティング支援.jpに参加するクレス(株)のモバイル 「デカEC」は、携帯電話の小さな画面でも簡単なキー操作で自由自在 モバイル画像拡大サービス「デカフラ」に関しましては、無料お試しキャ マーケティング支援.jpでは「デカEC」を第一弾と考え、マーケティング 4、デジタルブック技術「リアルリード」を採用し、アイ・エム・プレス出版 閲覧者のニーズにお応えし、パートナー選びの指針となるマーケティング 1、全文書SEO対策、 などです。 今後、「マーケティング支援.jp」では総合的なマーケティング支援サイト □ ■マーケティング支援.jpについて■□ “インターネット時代の顧客づくりを活性化する”マーケティング情報誌、 マーケターが抱える課題を解決すると同時に、ITやアウトソーシングなど ※ Internet Explorer 6.0以前のブラウザをご利用の方は <株式会社アイ・エム・プレスの概要>
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2007年12月03日 中高年のコミュニティサイト『A-ha』会員数2000人を突破 株式会社アイ・プランニング(本社:群馬県伊勢崎市、代表取締役:森岡 また、会員数増加に伴い、下記のように着実にアクセス増を得ることができました。 中高年層には、インターネットのコミュニケーションが活発でないイメージがありますが、 ーーーーーーーーーーーーーーーーーーーーーーーーーーーーーーーー |
2007年12月03日 報道関係者各位 ㈱アイコールは、NTT DoCoMoの公式コンテンツ向けに高品質で実施しておりました「きせかえツール」制作を一般(勝手)サイト向けに拡大いたします。モバイルサイトのコンテンツ拡充や企業PR用のツールとしてご活用頂けます。 その他製品のご案内
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2007年12月03日 ================================================
キャンパスの中で友人同士が語り合う姿や、 収録の写真素材は、すべてロイヤリティフリーなので、
▼sozaijiten.com(データクラフト 商品情報URL) ■データクラフトについて デザイナー向けのECサイト ━━━━━━━━━━━━━━━━━━━━━━━━━━━━━ 【本商品に関する問い合わせ先】 |
2007年12月03日 焼肉の大同門が新たなコンセプトで神戸三宮に2007年12月10日にNEW STYLEの焼肉店「神戸 星流苑」をオープンさせていただきます。 [神戸星流苑の名前の由来] 「豊かな海と山並みに囲まれた町「神戸」 [商品へのこだわり] 「新鮮な地元の食材をその地で美味しく食べる」「地産地消」の考えから、 [店内イメージ] エントランスは、ウォーターカーテンでお出迎えいたします。 『レセプション 開催日時』 「日時」12月6日(木)18時00分~20時30分 「場所」兵庫県神戸市中央区北長狭通1-9-3 TEL 078-325-1400 FAX 078-325-1401
担当 綾城高志(あやしろたかし) t_ayashiro@daidomon.com |
2007年12月03日 ~ .NET Framework が GIS を変える ~ 業界初の .NETテクノロジーを使ったプラグイン型 GIS 開発環境 MapQuestSimpleApplicationFramework【構築 Pro】のご紹介セミナーを無料開催。定員残りわずかですのでお申込はお早めに。
●セミナーの詳細はこちらをご覧下さい。
■第1部 GISエンジン : MapQuestDotNET ■第2部 プラグイン型GIS開発環境 : 構築Pro ■第3部 WebGISエンジン : MapQuestWebサーバーコントロール ■質疑応答 ------------------------------------------------------------------- ■日 時:2007年12月10日(月)13:30~16:30(受付開始:13:00より) |
2007年12月03日 株式会社オンテックス(大阪府大阪市)の代表取締役会長兼CEO小笹公也は、株式会社リンクアンドモチベーション(東京都中央区)の代表取締役社長 小笹芳央氏との共著により、2007年11月22日に、『自分のカラを破る力が湧く言葉』を株式会社経済界より発刊致しました。 【本書の特徴】 (2)対照的な二人の人生論対談! 【概要】 【著者プロフィール】
■株式会社オンテックス http://www.ontex.co.jp/ |
2007年12月03日 報道関係者各位 甲乙株式会社(東京都世田谷区、代表取締役:小泉健司)は、本日2007年12月1日よりスポットランキングサイト『甲乙スポットランキング』(http://www.kouotu.com/)を運用開始いたしました。『甲乙スポットランキング』は、店などのスポットをみんなでランキングし、ランキングを統計した結果をみんなの意見としてスポット検索できる、地域に特化したソーシャルネットワーキングサービスです。 《サイトの特徴》 《サイトのねらい》 《サイトの概要》 ―――――――――――――――――――――――――――――――――― |